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KMID : 0665220030160040437
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Korean Journal of Food and Nutrition
2003 Volume.16 No. 4 p.437 ~ p.443
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Acute Oral Toxicity of Chitooligosaccharides in Mice
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Park Heon-Kuk
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Abstract
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Chitooligosaccharides were prepared by enzymatic hydrolyzing of crab shell chitosan. Low molecular weight chitooligosaccharides(LMW-chitooligosaccharides), 64.3% of which was composed of trimer, tetramer, and pentamer, was obtained by hydrolyzing chitosan with the chitosanase originated Bacillus pumilus BN-262. High molecular weight chitooligosaccharides(HMW-chitooligosaccharides), 49.3% of which was composed of chitooligosaccharides over heptamer, was obtained by hydrolyzing chitosan with the cellulase originated Trichoderma viride. Acute oral toxicity of chitooligosaccharides were tested in mice. Chitooligosaccharides did not have any toxic effect in mice and oral LD$\_$50/ value of chitooligosaccharides was over 5.0g/kg in mice.
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KEYWORD
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chitooligosaccharides, acute oral toxicity, mice
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